A natural product phillygenin suppresses osteosarcoma growth and metastasis by regulating the SHP-1/JAK2/STAT3 signaling

ABSTRACT Osteosarcoma represents one of the most devastating cancers due to its high metastatic potency and fatality. is insensitive traditional chemotherapy. Identification a small molecule that blocks osteosarcoma progression has been challenge in drug development. Phillygenin, plant-derived tetrahydrofurofuran lignin, shown suppress cancer cell growth inflammatory response. However, how phillygenin plays functional roles remained unveiled. In this study, we showed inhibited motility vitro. Further mechanistic studies indicated blocked STAT3 signaling pathway. Phillygenin led significant downregulation Janus kinase 2 upregulation Src homology region domain-containing phosphatase 1. Gene products regulating survival invasion were also by phillygenin. Therefore, our provided first evidence repressed interfering potential candidate therapy.